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The following is a review of diagnostics related medical research worldwide

The information is updated the first week of every month - so ... make this a regular stop in your information gathering activities.

The following information has been compiled from publicly available Sources, StratCom does not assume any responsibility for the accuracy or the authenticity of the information and StratCom cannot be held liable for errors.

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Research News for October 1999

The Cancer Genome Project, based at the Sanger Centre in eastern England, is a new initiative to use data from the Human Genome Project to identify all the genes that cause cancer. The project will be funded with a $16.69 million grant from the Wellcome Trust, and plans to use the genetic blueprint of the approximately 100,000 genes in the human genome to better understand how cancer develops and to speed up the development of new drugs to combat the disease. The Sanger Centre is part of an international consortium working on the Humane Genome Project which is scheduled to complete the human genetic blueprint in 2003.

Scientists at the National Institutes of Health (NIH) examined the brains of people who had died from Alzheimer's Disease and found abnormally large amounts of the cellular signpost--a normal enzyme in the body called casein kinase-1 (CK- 1). The researchers found that a high level of CK-1 was present in nerve cells inside cellular sacs called vacuoles. The findings indicate that a high CK-1 level in vacuoles may be a useful marker for AD, along with the two other long- recognized cellular abnormalities, or "lesions," associated with the disease: plaques and tangles.
Source: American Journal of Pathology, October 1999

Researchers at the Cancer Research Campaign Institute at Cambridge University, England are developing an urine test to detect bladder cancer in its early stages and could be adapted to test for colon, prostate and other cancers. The test detects Mcm5, a protein required for cell growth that tells DNA to replicate itself and is found in high concentrations in many cancers. The protein is shed in large amounts from cancer cells into the urine and could reduce the number of people who are forced to undergo risky biopsies by ruling out those whose suspicious symptoms are not related to cancer.
Source: The Lancet, October 1999

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