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The following is a review of diagnostics related medical research worldwideThe information is updated the first week of every month - so ... make this a regular stop in your information gathering activities.The following information has been compiled from publicly available Sources, StratCom does not assume any responsibility for the accuracy or the authenticity of the information and StratCom cannot be held liable for errors.
Research News for February 2000
A team of researchers led by Dr. Stephan Braun of Ludwig Maximilians University in Munich, Germany, is developing a screening test that looks for cancer-related cytokeratin proteins in bone marrow. The assay may help identify women with breast cancer that are most likely to have a recurrence of the disease. At the time of surgery to remove a malignant breast tumor, it is standard procedure to test lymph nodes for cancer to see if the disease has spread outside the breast. The results of the examination of the lymph nodes, which are found in the armpit, help in deciding further treatment. However determining prognosis based on the presence or absence of cancer cells in the nodes is not always accurate. By detecting cytokeratins, which are normally found in breast cancer cells but not in bone marrow, the test identifies women who have tiny tumor deposits called micrometastases in their bone marrow. Researchers at the University of Chicago have found that low levels of E-cadherin, a protein that helps link cells together may be the most effective factor for predicting which patients with early breast cancer need chemotherapy after surgery. They found by adding E-cadherin to other biomarkers they were able to distinguish those patients with a 90% long-term survival from those whose survival is only 44%.
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