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The following is a review of diagnostics related medical research worldwide

The information is updated the first week of every month - so ... make this a regular stop in your information gathering activities.

The following information has been compiled from publicly available Sources, StratCom does not assume any responsibility for the accuracy or the authenticity of the information and StratCom cannot be held liable for errors.

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Research News for November 2000

Matritech is developing a blood-based colon cancer test that detects the presence of proteins in the blood of individuals with colon cancer, and multiple and/or high-risk polyps, the precursors to colon cancer. The company intends to use these proteins as the basis for cancer tests for the early detection of people at risk, which could enable treatment before disease progression.

Researchers at the Mayo Clinic are developing an assay to detect mutations in DNA in stool samples to screen for colorectal cancers and adenomas. A multicenter team of investigators developed an assay that targets highly amplifiable human DNA isolated from stool samples, a microsatellite instability marker, and mutations in the K-ras, p53 and APC oncogenes. They tested the assay in archived samples from 22 patients with colorectal cancer, 11 patients with adenomas at least 1 cm in diameter and 28 patients with normal colons. The test detected 20 of the 22 cancers, translating to a sensitivity of 91%, and the sensitivity in detecting adenomas was 82%.
Source: Gastroenterology November 2000;119:1219-1227.

Myriad Genetics, Inc. has discovered six potential drug targets involved in the regulation of lipid metabolism. The new targets are part of the disease pathway of the CHD1 (Coronary Heart Disease 1) gene and were identified through Myriad's proprietary proteomics technology, ProNet. Myriad researchers discovered the CHD1 (ZNF202) gene in a collaboration with Novartis that focused on the identification of major heart disease causing genes.

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