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The following information has been compiled from publicly available sources, StratCom does not assume any responsibility for the accuracy or the authenticity of the information and StratCom cannot be held liable for errors.

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Molecular Biology — December 2001

Agilent Laboratories has entered into a collaboration with The University of Colorado and DARPA, to develop a two-step process for the chemical synthesis of nucleic acids. Agilent re[ports that "The two-step process would represent the first major breakthrough in the synthesis of nucleic acids in 20 years. The current approach was developed by Marvin Caruthers and his co-workers at the University of Colorado more than 20 years ago."

Ciphergen Biosystems has introduced its ProteinChip Biomarker System for biomarker pattern recognition analysis. The system allows researchers to ask and rapidly answer clinical questions by investigating the proteome from crude clinical samples ranging from laser capture micro-dissected cells, biopsies, tissue, urine and serum using Ciphergen's patented ProteinChip Array based Expression Difference Mapping and integrated SELDI-TOF-MS detection processes. The system utilizes Biomarker Patterns software, which automates pattern recognition-based statistical analysis methods to correlate protein expression patterns from clinical samples with disease phenotypes.

DNAPrint genomics, Inc. has entered into a collaboration with the New York University School of Medicine to develop pharmacogenomic classifiers for organ transplant patients. The goal of the project is to identify pharmacogenomic classifiers that could be used to match renal transplantation patients with the optimal immunosuppressant for their genetic architecture. The project is expected to take about one year to complete, and the results are expected to extend to patients for a wide range of transplantation procedures.

Interleukin Genetics, Inc. has entered into a research collaboration with Kaiser Permanente's Center for Health Research in Portland, Ore., to study genetic risk factors for chronic diseases that are affected by inflammation. Knowledge resulting from this work will enable Interleukin Genetics to develop new diagnostic tools that physicians and health care organizations can use to assess their patients' genetic risks for many diseases.

Nanogen, Inc.has developed a research protocol for S65C, a mutation associated with Hereditary Hemochromatosis. The protocol is for use in research laboratories on the NanoChip Molecular Biology Workstation. Nanogen anticipated that users of the protocol will include CLIA certified laboratories that will have the option to further develop and validate the protocol for internal use in a "home-brew" format. Nanogen has already released five DNA-based research protocols: Factor II, Factor V, a Factor II and Factor V multiplex format, and MTHFR.

Pyrosequencing AB's Molecular Diagnostics Business Unit and the Mayo Foundation for Education and Research are collaborating to develop tests to detect an inherited form of thyroid cancer known as multiple endocrine neoplasia type 2 (MEN 2). Mayo Clinic will use Pyrosequencing(TM) technology for the rapid and accurate identification of RET gene mutations associated with MEN 2.

Xtrana, Inc., and CUNO Incorporated have signed a joint development and license agreement to combine Xtrana's Xtra Bind proprietary nucleic acid extraction technologies with CUNO's nylon microporous membranes for improved nucleic-acid sample preparation. The new product, Xtra Bind Nylon-XBN membrane, will become the key component of a fully-integrated sample preparation, amplification, and detection system to be developed and marketed by Xtrana. The system is designed for rapid testing for the identification of microorganism species and strain.

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* Molecular Biology - November 2001
* Molecular Biology - October 2001
* Molecular Biology - September 2001
* Molecular Biology - Summer 2001
* Molecular Biology - May 2001
* Molecular Biology - April 2001
* Molecular Biology - March 2001
* Molecular Biology - February 2001
* Molecular Biology - January 2001
* Molecular Biology - December 2000
* Molecular Biology - November 2000
* Molecular Biology - October 2000
* Molecular Biology - September 2000
* Molecular Biology - July - August 2000
* Molecular Biology - June 2000
* Molecular Biology - May 2000
* Molecular Biology - April 2000
* Molecular Biology - March 2000
* Molecular Biology - Febuary 2000
* Molecular Biology - January 2000
* Molecular Biology - December 1999
* Molecular Biology - November 1999
* Molecular Biology - October 1999
* Molecular Biology - September 1999

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