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The following information has been compiled from publicly available sources, StratCom does not assume any responsibility for the accuracy or the authenticity of the information and StratCom cannot be held liable for errors.

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Molecular Biology — October 2003

Abbott Laboratories and artus GmbH have launched real time PCR tests to detect infectious diseases: The SARS test, the RealArt HPA Coronavirus PCR Kit, RealArt C. trachomatis PCR Kit, and the RealArt M. tuberculosis PCR Reagents. The tests are developed for use on the Applied Biosystems ABI PRISM 7000 Sequence Detection System by artus in collaboration with the Bernhard-Nocht- Institute for Tropical Medicine in Hamburg, Germany. All three tests are available throughout the world, except in the US, Canada and Japan.

Agilent Technologies Inc. has introduced the Agilent Total RNA Isolation Mini Kit, a new RNA Isolation kit designed to remove up to 1,000 times more genomic DNA than competing products. The kit does not require the use of DNase enzyme, which is commonly used to remove genomic DNA but can compromise the quality of RNA. The kit is designed to isolate total RNA from tissues and cells for use in microarray-based gene expression, real-time PCR experiments, and other applications. PCR is a widely used process for copying and quantifying DNA or RNA.

PreAnalytiX GmbH and Affymetrix Inc. are collaborating to optimize the PreAnalytiX PAXgene Blood RNA System for use with Affymetrix GeneChip technology to improve gene expression profile results on RNA extracted from whole blood. The goal of the collaboration will be to develop improved methods for the use of PreAnalytiX technology with GeneChip expression analysis arrays.

SEQUENOM, Inc. is developing genetic markers in four genes for susceptibility to breast cancer. Each gene has forms that increase or decrease the risk for developing breast tumors.

STMicroelectronics has signed a joint development agreement with MobiDiag to create a complete system for genomic-based detection of infectious diseases based on a silicon MEMS biochip. A commercial product is expected to be available in 2005.

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